Detection of chromosomal aberration in fetuses arising from recurrent spontaneous abortion by comparative genomic hybridization

Abstract excerpt

Chromosomal abnormalities (mostly aneuploidy) account for approximately 50% of fetal losses in the first 8-15 weeks of gestation. Cytogenetic analysis of aborted fetal material depends on conventional tissue culturing and karyotyping. This technique is laborious and is subject to problems including external contamination, culture failure and selective growth of maternal cells. Comparative genomic hybridization...

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