A rapid method of haplotyping HFE mutations and linkage disequilibrium in a Caucasoid population.

doi:10.1136/gut.42.4.566

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Article

A rapid method of haplotyping HFE mutations and linkage disequilibrium in a Caucasoid population.

Gut - 1 Apr 1998

Mullighan C G, Bunce M, Fanning G C, Marshall S E, Welsh K I

Abstract excerpt

BACKGROUND: HFE mutations are associated with hereditary haemochromatosis. However, a simple method capable of demonstrating the cis/trans arrangement of alleles is lacking, and linkage disequilibrium between HFE alleles and classic HLA loci is unknown. These are important issues as the pathogeni...

Topics

Alleles
Genes, MHC Class I
Haplotypes
Hemochromatosis
Humans
Linkage Disequilibrium
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Tagged Sites
White People

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