Susceptibility of Human Placental Syncytiotrophoblastic Mitochondria to Oxygen-Mediated Damage in Relation to Gestational Age1

Abstract excerpt

When maintaining first trimester placental villi in organ culture under conventional normoxic conditions, we have observed widespread degeneration of the syncytiotrophoblast within 24 h despite excellent viability for the cytotrophoblastic and stromal cell types. Here we identify loss of mitochondrial activity as an early event in this process. In the light of proposals that the early part of gestation occurs in...

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