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Article

Role of the negative charges in the cytosolic domain of TOM22 in the import of precursor proteins into mitochondria.

Molecular and cellular biology - 1 Jun 1998

Nargang F E, Rapaport D, Ritzel R G, Neupert W, Lill R

Abstract excerpt

TOM22 is an essential mitochondrial outer membrane protein required for the import of precursor proteins into the organelles. The amino-terminal 84 amino acids of TOM22 extend into the cytosol and include 19 negatively and 6 positively charged residues. This region of the protein is thought to interact with positively charged presequences on mitochondrial preproteins, presumably via electrostatic interactions. We...

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Identifiers

PMID: 9584158
DOI: 10.1128/MCB.18.6.3173
PMCID: PMC108899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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