Article
Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.
Genome research - 1 May 1998
Gingeras T R, Ghandour G, Wang E, Berno A, Small P M, Drobniewski F, Alland D, Desmond E, Holodniy M, Drenkow J
Abstract excerpt
High-density oligonucleotide arrays can be used to rapidly examine large amounts of DNA sequence in a high throughput manner. An array designed to determine the specific nucleotide sequence of 705 bp of the rpoB gene of Mycobacterium tuberculosis accurately detected rifampin resistance associated...
Topics
- Alleles
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Gene Frequency
- Genes, Bacterial
- Genotype
- Molecular Sequence Data
- Mutagenesis
- Mycobacterium
- Mycobacterium tuberculosis
- Nucleic Acid Hybridization
- Oligonucleotides
- Polymorphism, Genetic