Article
Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.
Genome research - 1 May 1998
Gingeras T R, Ghandour G, Wang E, Berno A, Small P M, Drobniewski F, Alland D, Desmond E, Holodniy M, Drenkow J
Abstract excerpt
High-density oligonucleotide arrays can be used to rapidly examine large amounts of DNA sequence in a high throughput manner. An array designed to determine the specific nucleotide sequence of 705 bp of the rpoB gene of Mycobacterium tuberculosis accurately detected rifampin resistance associated with mutations of 44 clinical isolates of M. tuberculosis. The nucleotide sequence diversity in 121 Mycobacterial...
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