Article
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases.
The Biochemical journal - 15 May 1998
Hurst R, Bao Y, Jemth P, Mannervik B, Williamson G
Abstract excerpt
Human glutathione transferases (GSTs) from Alpha (A), Mu (M) and Theta (T) classes exhibited glutathione peroxidase activity towards phospholipid hydroperoxide. The specific activities are in the order: GST A1-1>GST T1-1>GST M1-1>GST A2-2>GST A4-4. Using a specific and sensitive HPLC method, specific activities towards the phospholipid hydroperoxide,1-palmitoyl-2-(13-hydroper oxy-cis-9, trans-11...
Topics
- Binding Sites
- Dinitrochlorobenzene
- Glutathione
- Glutathione Peroxidase
- Glutathione Transferase
- Humans
- Isoenzymes
- Kinetics
- Lipid Peroxides
- Mutation
- Phospholipid Hydroperoxide Glutathione Peroxidase