Article
Mitochondrial DNA deletion is a predisposing cause for sensorineural hearing loss.
The Laryngoscope - 1 Apr 1998
Ueda N, Oshima T, Ikeda K, Abe K, Aoki M, Takasaka T
Abstract excerpt
Composed of a postmitotic stable tissue, the inner ear is a target organ for mitochondrial DNA (mtDNA) mutation. To determine whether mtDNA mutation is a predisposing factor in patients with sensorineural hearing loss (SNHL), the authors assessed the mtDNA4977 deletion from 60 patients with SNHL and 47 normal control subjects. All cases had no past history of ototoxic or noise exposure, middle ear disease, or...
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