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Article

Deleterious mutations destabilize ribosomal RNA in endosymbiotic bacteria.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998

Lambert J D, Moran N A

Abstract excerpt

In populations that are small and asexual, mutations with slight negative effects on fitness will drift to fixation more often than in large or sexual populations in which they will be eliminated by selection. If such mutations occur in substantial numbers, the combined effects of long-term asexuality and small population size may result in substantial accumulation of mildly deleterious substitutions. Prokaryotic...

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Identifiers

PMID: 9539759
DOI: 10.1073/pnas.95.8.4458
PMCID: PMC22511

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