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Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade

1 Mar 1998

Abstract excerpt

We analyzed 72 primary and 25 recurrent glioblastoma multiforme (GBM) samples for DNA sequence copy number abnormalities (CNAs) by comparative genomic hybridization (CGH). The number of aberrations per tumor ranged from 2 to 23 in primary GBM and 5 to 25 in recurrent GBM. There were 26 chromosome regions with CNAs in more than 20% of tumors. 7q22-36 was the most common gain and 10q25-26 was the most common loss;...

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PMID: 9523194
DOI: 10.1002/(sici)1098-2264(199803)21:3<195::aid-gcc3>3.0.co;2-v

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