Prevalence of Human Papillomavirus in Squamous Cell Carcinoma of the Head and Neck Determined by Polymerase Chain Reaction and Southern Blot Hybridization: Proposal for Optimized Diagnostic Requirements

Abstract excerpt

Human papillomaviruses (HPV) are discussed as cofactors in the carcinogenesis of squamous cell carcinoma of the head and neck (SCCHN). The prevalence of HPV infection in SCCHN is the subject of controversy since reported HPV prevalences range from less than 10% to almost 100%, depending mainly on the detection method employed. This study presents a realistic approximation to the real prevalence of HPV in SSCHN by...

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