The co-ordination of nuclear and organellar genome expression in eukaryotic cells.

Abstract excerpt

Mitochondria and chloroplasts contain their own genetic complement. Eukaryotic cells must establish mechanisms by which the organellar and nuclear genomes are co-ordinately expressed. In the yeast S. cerevisiae, mitochondrial mutants that have respiratory deficiencies have altered patterns of nuclear gene expression. In strains that are deficient in the mitochondrial isoform of citrate synthase there is an...

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