Article
Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts.
The Journal of biological chemistry - 20 Feb 1998
Isobe K, Ito S, Hosaka H, Iwamura Y, Kondo H, Kagawa Y, Hayashi J I
Abstract excerpt
We addressed the question of whether both mitochondrial and cytoplasmic translation activities decreased simultaneously in human skin fibroblasts with the age of the donors and found that the age-related reduction was limited to mitochondrial translation. Then, to determine which genome, mitochondrial or nuclear, was responsible for this age-related, mitochondria-specific reduction, pure nuclear transfer was...
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