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Article

Transforming Growth Factor β1 and β2 Reduce the Number of Gonocytes by Increasing Apoptosis<sup>1</sup>

1 Feb 1998

Abstract excerpt

Transforming growth factors beta1 and beta2 (TGFbetas) have recently been detected by immunohistochemistry in the fetal and neonatal rat testis, and the aim of the present study was to determine whether these factors can act as local regulators to control the number of gonocytes. Testes were kept in organ culture, and TGFbeta1 was found to have dose-dependent inhibitory effect on the number of gonocytes in testes...

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PMID: 9449647
DOI: 10.1210/endo.139.2.5765

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