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Article

Paramyxovirus RNA Synthesis and the Requirement for Hexamer Genome Length: the Rule of Six Revisited

1 Feb 1998

Abstract excerpt

The template for paramyxovirus RNA synthesis is not naked RNA but the helical nucleocapsid core of the virus, in which each nucleocapsid protein (N protein) is predicted to be associated with precisely 6 nucleotides (nt) (11). Presumably as a consequence of this association, paramyxovirus genomes are replicated efficiently only when they are a multiple of 6 nt in length, and this has been dubbed the “rule of six”...

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PMID: 9444980
DOI: 10.1128/jvi.72.2.891-899.1998

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