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Asian genotypes of JC virus in Native Americans and in a Pacific Island population: Markers of viral evolution and human migration

23 Dec 1997

Abstract excerpt

The human polyomavirus JC (JCV) causes the central nervous system demyelinating disease progressive multifocal leukoencephalopathy. Previously, we showed that 40% of Caucasians in the United States excrete JCV in the urine as detected by PCR. We have now studied 68 Navaho from New Mexico, 25 Flathead from Montana, and 29 Chamorro from Guam. By using PCR amplification of a fragment of the VP1 gene, JCV DNA was...

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PMID: 9405649
DOI: 10.1073/pnas.94.26.14542

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