The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.

doi:10.1046/j.1471-4159.1997.69062251.x

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Article

The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.

Journal of neurochemistry - 1 Dec 1997

Barnes T M, Hekimi S

Abstract excerpt

Mutations in the unc-9 gene of the nematode Caenorhabditis elegans cause abnormal forward locomotion and an egg-retention phenotype. unc-9 mutations also reduce the worms' sensitivity to avermectin and block a form of hypersensitivity to volatile anesthetics. We report here the cloning and molecu...

Topics

Alleles
Amino Acid Sequence
Anesthetics
Animals
Anthelmintics
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cloning, Molecular
Female
Gap Junctions
Helminth Proteins
Insecticide Resistance
Ivermectin
Membrane Proteins
Molecular Sequence Data
Motor Activity
Mutation
Oviposition

Source

Open in PubMed

Identifiers

PMID: 9375655
DOI: 10.1046/j.1471-4159.1997.69062251.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9375655-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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