Genetic factors in osteoporosis. What are the implications for prevention and treatment?

Abstract excerpt

Osteoporosis is a common disease that affects 1 in 3 women. Family and twin studies have demonstrated that there is a strong genetic component to this condition. Potential candidate genes examined for their regulatory effect on bone mass include those for collagen type I, estrogen and vitamin D receptors, and various cytokines and growth factors. To date, most work has focused on the vitamin D receptor (VDR)...

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