Aerobic and anaerobic regulation of the ubiCA operon, encoding enzymes for the first two committed steps of ubiquinone biosynthesis in Escherichia coli.

Abstract excerpt

The ubiCA operon of Escherichia coli encodes enzymes for the first two steps of ubiquinone biosynthesis. A monolysogen (ubiC-lacZ operon fusion) was constructed to study ubiCA regulation. Expression was higher during aerobic growth than anaerobically, and increased with rate of oxygen supply. Although ubiquinone is implicated in antioxidant roles, ubiC expression was not elevated in response to hydrogen peroxide...

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