An evaluation of the application of the genetic algorithm to the problem of ordering genetic loci on human chromosomes using radiation hybrid data.

Abstract excerpt

We consider the problem of ordering detectable genetic loci along a chromosome by minimizing the number of obligatory breaks that can be inferred from radiation hybrid data. The problem bears some resemblance to the travelling-salesman problem, for which genetic algorithms have been used with considerable success. We find that the results from other studies on closely related problems are not directly...

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