Article
Non-founder mutations in the MEFV gene establish this gene as the cause of familial Mediterranean fever (FMF).
Human molecular genetics - 1 Aug 1998
Bernot A, da Silva C, Petit J L, Cruaud C, Caloustian C, Castet V, Ahmed-Arab M, Dross C, Dupont M, Cattan D, Smaoui N, Dodé C, Pêcheux C, Nédelec B, Medaxian J, Rozenbaum M, Rosner I, Delpech M, Grateau G, Demaille J, Weissenbach J, Touitou I
Abstract excerpt
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurring attacks of fever and serositis. It affects primarily North African Jews, Armenians, Turks and Arabs, in which a founder effect has been demonstrated. The marenostrin-pyrin-encoding gene has been propo...
Topics
- Africa, Northern
- Amino Acid Sequence
- Cytoskeletal Proteins
- Exons
- Familial Mediterranean Fever
- Haplotypes
- Humans
- Molecular Sequence Data
- Mutation
- Proteins
- Pyrin
- Sequence Analysis