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Article

Sudden cardiac death in familial hypertrophic cardiomyopathy: are "benign" mutations really benign?

Pathology - 1 Aug 1997

Semsarian C, Yu B, Ryce C, Lawrence C, Washington H, Trent R J

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disorder characterised predominantly by left ventricular hypertrophy and sudden cardiac death. Mutations in the cardiac beta-myosin heavy chain gene have been identified in several families and designated as "benign" or "malignan...

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Identifiers

PMID: 9271024
DOI: 10.1080/00313029700169155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9271024-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Sudden cardiac death in familial hypertrophic cardiomyopathy: are "benign" mutations really benign?PMID 9271024Read ↗

Malignant mutations in hypertrophic cardiomyopathy: fact or fancy?Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy caused by a de novo Gly716Arg mutation of the β-myosin heavy chain.Semantic proximity Read ↗

Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Sudden death due to troponin T mutations.Semantic proximity Read ↗

Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical beta-myosin heavy chain gene mutations.Semantic proximity Read ↗

Sudden cardiac death in hypertrophic cardiomyopathy. Variability in phenotypic expression of beta-myosin heavy chain mutations.Semantic proximity Read ↗

Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective.Semantic proximity Read ↗

DNA testing in familial hypertrophic cardiomyopathy: clinical and laboratory implications.Semantic proximity Read ↗

Malignant hypertrophic cardiomyopathy caused by the Arg723Gly mutation in beta-myosin heavy chain gene.Semantic proximity Read ↗

[Direct detection of malignant mutations in patients with hypertrophic cardiomyopathy].Semantic proximity Read ↗

A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophySemantic proximity Read ↗

A novel missense mutation, Leu390Val, in the cardiac beta-myosin heavy chain associated with pronounced septal hypertrophy in two families with hypertrophic cardiomyopathy.Semantic proximity Read ↗

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