Article
The antiandrogen withdrawal syndrome.
Urological research - 1 Jan 1997
Wirth M P, Froschermaier S E
Abstract excerpt
In 1989 the unanticipated agonist effect of antiandrogens on LNCaP prostate cancer cells was detected. A "flutamide withdrawal syndrome" was first described by Kelly and Scher [15], who reported a decrease in serum prostate-specific antigen (PSA) levels after the removal of flutamide from the tre...
Topics
- Androgen Antagonists
- Humans
- Male
- Mutation
- Neoplasms, Hormone-Dependent
- Prognosis
- Prostate-Specific Antigen
- Prostatic Neoplasms
- Receptors, Androgen
- Tumor Cells, Cultured