Article
The antiandrogen withdrawal syndrome.
Urological research - 1 Jan 1997
Wirth M P, Froschermaier S E
Abstract excerpt
In 1989 the unanticipated agonist effect of antiandrogens on LNCaP prostate cancer cells was detected. A "flutamide withdrawal syndrome" was first described by Kelly and Scher [15], who reported a decrease in serum prostate-specific antigen (PSA) levels after the removal of flutamide from the treatment regimen. In the last few years the paradoxical response to antiandrogens has also been reported for...
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