Article
Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139: specificity and relevance to immunity.
Clinical and diagnostic laboratory immunology - 1 May 1997
Losonsky G A, Lim Y, Motamedi P, Comstock L E, Johnson J A, Morris J G, Tacket C O, Kaper J B, Levine M M
Abstract excerpt
The emergence of a new agent of cholera, Vibrio cholerae O139, has prompted a reevaluation of the vibriocidal antibody assay. This assay, primarily directed to lipopolysaccharide, is an important correlate of O1 immunity. V. cholerae O139 strains are encapsulated, rendering them relatively resistant to killing by serum. Recent reports suggest that there is strain-to-strain variability in the sensitivity of the...
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