Article
Hb T-Cambodia, a beta chain variant with the mutations of Hb E and Hb D-Punjab, confirmed by DNA analysis.
Hemoglobin - 1 May 1997
Hutt P J, Fairbanks V F, Thibodeau S N, Green M M, Hoyer J D, Block S H, Day C, Jones R T, Barwick R C
Abstract excerpt
Hemoglobin variants with two amino acid substitutions affecting one globin chain are relatively rare. Hb T-Cambodia, a doubly substituted beta-globin variant, was characterized previously by amino acid sequencing as having sequence alterations in beta 26 (beta 8)Glu-->Lys and beta 121(GH4) Glu-->...
Topics
- Adult
- Blood Protein Electrophoresis
- Chromatography, High Pressure Liquid
- Exons
- Hemoglobin E
- Hemoglobins
- Hemoglobins, Abnormal
- Humans
- Male
- Mutation
- Pedigree
- Peptides
- Sequence Analysis, DNA
- Trypsin