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Article

Hb O-Arab [beta 121(GH4)Glu-->Lys]: association with DNA polymorphisms of African ancestry in two Mediterranean families.

Hemoglobin - 1 Dec 1993

Lacerra G, Fioretti G, Hani A, Duka D, De Angioletti M, Pagano L, Viola A, Desicato S, Ferranti P, Pucci P

Abstract excerpt

Hb O-Arab [beta 121(GH4)Glu-->Lys] was detected in two Mediterranean families, one from Southern Italy and the other from Albania. The GAA-->AAA mutation at codon 121 was characterized by DNA sequencing. The mutant genes were associated with the same beta-globin gene framework variant and with th...

Topics

Adolescent
Africa
Albania
Base Sequence
DNA
Globins
Hemoglobins, Abnormal
Humans
Italy
Middle Aged
Molecular Sequence Data
Mutation
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7908281
DOI: 10.3109/03630269309043492

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7908281-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 8 closest

Hb O-Arab [beta 121(GH4)Glu-->Lys]: association with DNA polymorphisms of African ancestry in two Mediterranean families.PMID 7908281Read ↗

Co-inheritance of Hb D-Punjab (codon 121; GAA-->CAA) and beta (0) -thalassemia (IVS-II-1;G-->A).Semantic proximity Read ↗

Hb St. Francis [beta 121(GH4)Glu----Gly]: a new mutation at the same site as Hb D-Los Angeles.Semantic proximity Read ↗

An alpha0-thalassemia-like mutation: Hb Suan-Dok [alpha109(G16)Leu-->Arg] carried by a recombinant -alpha(3.7) gene.Semantic proximity Read ↗

The mutation associated with Hb Peterborough [beta111(G13)Val-->Phe] originated from Southern Italy.Semantic proximity Read ↗

Hb T-Cambodia, a beta chain variant with the mutations of Hb E and Hb D-Punjab, confirmed by DNA analysis.Semantic proximity Read ↗

A new, electrophoretically silent, fetal hemoglobin variant: Hb F-Calabria [Ggamma118(GH1)Phe-->Leu].Semantic proximity Read ↗

[Dominant beta-thalassemia alleles in the Czech and Slovak population (beta-thalassemia mutations in 112(T-A) and 121(G-T) codons and the unstable Hradec Králové hemoglobin or alpha 2 beta 2 115 (G17) Ala-Asp)].Semantic proximity Read ↗

Hb D-Agri [beta9(A6)Ser --> Tyr;beta121(GH4)Glu --> Gln]: a new Indian hemoglobin variant with two amino acid substitutions in the same beta chain.Semantic proximity Read ↗

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