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Article

Compound heterozygosity for two novel missense mutations in the prothrombin gene in a patient with a severe bleeding tendency.

Thrombosis and haemostasis - 1 Apr 1997

Poort S R, Landolfi R, Bertina R M

Abstract excerpt

The abnormal prothrombin gene of an Italian patient with a severe bleeding tendency and hypoprothrombinemia was selected for study and compared with the prothrombin genes of healthy controls. All the coding and their flanking regions and the 5'- and 3'-UT regions of the prothrombin gene were screened by analyzing the nucleotide sequence of the corresponding PCR products. The patient was found to be heterozygous...

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PMID: 9134629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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