Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G.

doi:10.1126/science.275.5302.990

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Article

Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G.

Science (New York, N.Y.) - 14 Feb 1997

Cooper P K, Nouspikel T, Clarkson S G, Leadon S A

Abstract excerpt

In normal human cells, damage due to ultraviolet light is preferentially removed from active genes by nucleotide excision repair (NER) in a transcription-coupled repair (TCR) process that requires the gene products defective in Cockayne syndrome (CS). Oxidative damage, including thymine glycols, is shown to be removed by TCR in cells from normal individuals and from xeroderma pigmentosum (XP)-A, XP-F, and XP-G...

Read the complete abstract on PubMed

Topics

Cockayne Syndrome
DNA
DNA Damage
DNA Repair
DNA-Binding Proteins
Endonucleases
Genetic Complementation Test
Humans
Hydrogen Peroxide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Oxidation-Reduction

Transcription Factors

Transcription, Genetic

Ultraviolet Rays

Xeroderma Pigmentosum

Source

Open in PubMed

Identifiers

PMID: 9020084
DOI: 10.1126/science.275.5302.990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.