Article
Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death.
Journal of cardiovascular electrophysiology - 1 Mar 1996
Moïse N S, Moon P F, Flahive W J, Brittain D, Pride H P, Lewis B A, Zipes D P, Lee R J, Gilmour R F
Abstract excerpt
INTRODUCTION: Dogs with an inherited predisposition to sudden death display ventricular arrhythmias having certain characteristics, such as pause dependence, that are suggestive of early afterdepolarization-induced triggered activity. We hypothesized that alpha-adrenergic stimulation may facilitate the development of these arrhythmias by inducing a reflex bradycardia and by exerting a direct myocardial effect....
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