Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 1996

Messier T L, Wong C Y, Bovill E G, Long G L, Church W R

Abstract excerpt

A unique blood coagulation factor X variant has been identified in a family with a history of bleeding. Plasma from affected family members had prolonged prothrombin times and activated partial thromboplastin times, low to below normal factor X coagulant activity, and normal factor X antigen levels. Sequencing of DNA from the propositus revealed a single G to A substitution in one allele of factor X at base 964...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Binding Sites

Share to Factor X

Share to Molecular Sequence Data

Share to Partial Thromboplastin Time

Share to Pedigree

Source

Identifiers

PMID: 8845463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X.PMID 8845463Read ↗

A novel type I factor X variant (factor X Cys350Phe) due to loss of a disulfide bond in the catalytic domain.Semantic proximity Read ↗

Diagnosis and treatment of inherited factor X deficiency.Semantic proximity Read ↗

Factor X deficiency.Semantic proximity Read ↗

Structure and function of factor XI.Semantic proximity Read ↗

A new factor X defect (factor X Padua 3): a compound heterozygous between true deficiency (Gly(380)-->Arg) and an abnormality (Ser(334)-->Pro).Semantic proximity Read ↗

Factor X and its deficiency statesSemantic proximity Read ↗

Prothrombin Padua I: incomplete activation due to an amino acid substitution at a factor Xa cleavage site.Semantic proximity Read ↗

Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate.Semantic proximity Read ↗

Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management.Semantic proximity Read ↗

Factors XWenatchee I and II: compound heterozygosity involving two variant proteins.Semantic proximity Read ↗

A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family.Semantic proximity Read ↗

A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.