Article
A survey of FRAXE allele sizes in three populations.
American journal of medical genetics - 9 Aug 1996
Zhong N, Ju W, Curley D, Wang D, Pietrofesa J, Wu G, Shen Y, Pang C, Poon P, Liu X, Gou S, Kajanoja E, Ryynänen M, Dobkin C, Brown W T
Abstract excerpt
FRAXE is a fragile site located at Xq27-8, which contains polymorphic triplet GCC repeats associated with a CpG island. Similar to FRAXA, expansion of the GCC repeats results in an abnormal methylation of the CpG island and is associated with a mild mental retardation syndrome (FRAXE-MR). We surv...
Topics
- Alleles
- Base Sequence
- China
- Chromosome Mapping
- DNA Primers
- Ethnicity
- Europe
- Finland
- Fragile X Syndrome
- Humans
- Intellectual Disability
- Molecular Sequence Data
- New York
- Polymerase Chain Reaction
- Polymorphism, Genetic