Cladistic approaches to identifying determinants of variability in multifactorial phenotypes and the evolutionary significance of variation in the human genome.

Abstract excerpt

Genetic surveys based on detailed restriction site mapping or DNA sequencing allow one to identify many different classes of mutational change at the molecular level and to estimate the evolutionary history of the genetic variation (a haplotype tree). These two sources of information can be combined in a powerful fashion to test hypotheses about the evolutionary significance of genetic variation and to identify...

Topics

• Animals
• Evolution, Molecular
• Genetic Techniques
• Genetic Variation
• Genome, Human
• Genotype
• Haplotypes
• Humans
• Multigene Family
• Phenotype