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Article

Fluorodeoxyuridine-mediated cytotoxicity and radiosensitization require S phase progression

1 Jan 1996

Abstract excerpt

The role of cell cycle redistribution in fluoropyrimidine-mediated radiosensitization remains unresolved. To determine if radiosensitization resulted from the redistribution of cells into a sensitive phase of the cell cycle, we assessed fluorodeoxyuridine (FdUrd)-mediated radiosensitization in flow-sorted mid-S phase HT29 human colon cancer cells. We hypothesized that if FdUrd-mediated radiosensitization were...

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PMID: 8800198
DOI: 10.1080/095530096145003

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