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Article

Tyrosine and its catabolites: from disease to cancer.

31 Mar 1996

Abstract excerpt

Hereditary tyrosinemia type I (HT I, McKusick 276,700) is a metabolic disease with a pattern of autosomal recessive inheritance. The disease is caused by a deficiency of the enzyme involved in the last step in the degradation of the amino acid tyrosine, fumarylacetoacetate hydrolase (FAH). The result of this block is the accumulation of catabolites some of which have been proposed to be highly toxic due to their...

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Identifiers

PMID: 8790725
DOI: 10.18388/abp.1996_4530

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