Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Founder effect and prevalence of myotonic dystrophy in South Africans: molecular studies.

American journal of human genetics - 1 Aug 1996

Goldman A, Krause A, Ramsay M, Jenkins T

Abstract excerpt

A high prevalence of myotonic dystrophy (DM) has been described in South African Caucasoid Afrikaans-speaking families in the northern Transvaal. Evidence is presented for a strong founder effect, with a single haplotype occurring on 68% of all Caucasoid DM chromosomes; among the Afrikaans speake...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Black People
Share to Europe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Haplotypes

Share to Polymerase Chain Reaction

Share to Prevalence

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 8755933
PMCID: PMC1914714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8755933-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Founder effect and prevalence of myotonic dystrophy in South Africans: molecular studies.PMID 8755933Read ↗

A global haplotype analysis of the myotonic dystrophy locus: implications for the evolution of modern humans and for the origin of myotonic dystrophy mutations.Semantic proximity Read ↗

Myotonic dystrophy type 2: human founder haplotype and evolutionary conservation of the repeat tract.Semantic proximity Read ↗

Dutch myotonic dystrophy type 2 patients and a North-African DM2 family carry the common European founder haplotype.Semantic proximity Read ↗

A Founder Mutation in MYO7A Underlies a Significant Proportion of Usher Syndrome in Indigenous South Africans: Implications for the African Diaspora.Semantic proximity Read ↗

Evidence for a founder effect for pseudoxanthoma elasticum in the Afrikaner population of South Africa.Semantic proximity Read ↗

Highly Elevated Prevalence of Spinobulbar Muscular Atrophy in Indigenous Communities in Canada Due to a Founder EffectSemantic proximity Read ↗

Convergent myotonic dystrophy (DM) haplotypes: potential inconsistencies in human disease gene localization.Semantic proximity Read ↗

Ethnicity and myotonic dystrophy: a possible explanation for its absence in sub-Saharan Africa.Semantic proximity Read ↗

Founder mutations in the LDL receptor gene contribute significantly to the familial hypercholesterolemia phenotype in the indigenous South African population of mixed ancestry.Semantic proximity Read ↗

Haplotype analysis of genomic polymorphisms in and around the myotonic dystrophy locus in diverse populations of India.Semantic proximity Read ↗

Detection of linkage disequilibrium between the myotonic dystrophy locus and a new polymorphic DNA marker.Semantic proximity Read ↗

CTG repeats distribution and Alu insertion polymorphism at myotonic dystrophy (DM) gene in Amhara and Oromo populations of Ethiopia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.