Article
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.
The Journal of clinical investigation - 1 Aug 1996
Wei X, McLeod H L, McMurrough J, Gonzalez F J, Fernandez-Salguero P
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD) deficiency constitutes an inborn error in pyrimidine metabolism associated with thymine-uraciluria in pediatric patients and an increased risk of toxicity in cancer patients receiving 5-fluorouracil (5-FU) treatment. The molecular basis for DPD deficiency in...
Topics
- Alleles
- Antimetabolites, Antineoplastic
- Base Sequence
- Dihydrouracil Dehydrogenase (NADP)
- Fluorouracil
- Genotype
- Humans
- Molecular Sequence Data
- Mutation
- Oxidoreductases