Article
LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.
Cell - 12 Jul 1996
Frangiskakis J M, Ewart A K, Morris C A, Mervis C B, Bertrand J, Robinson B F, Klein B P, Ensing G J, Everett L A, Green E D, Pröschel C, Gutowski N J, Noble M, Atkinson D L, Odelberg S J, Keating M T
Abstract excerpt
To identify genes important for human cognitive development, we studied Williams syndrome (WS), a developmental disorder that includes poor visuospatial constructive cognition. Here we describe two families with a partial WS phenotype; affected members have the specific WS cognitive profile and vascular disease, but lack other WS features. Submicroscopic chromosome 7q11.23 deletions cosegregate with this...
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