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Article

Prolonged Metabolic Correction in Adult Ornithine Transcarbamylase-deficient Mice with Adenoviral Vectors

1 Feb 1996

Abstract excerpt

A murine model of ornithine transcarbamylase (OTC) deficiency was used in this study to evaluate the efficacy of recombinant adenoviruses for correcting the metabolic defect in liver. Recombinant adenoviruses deleted in E1 and containing a human OTC cDNA expressed little functional OTC enzyme in vivo and had no observable impact on the underlying metabolic abnormalities of the OTC-deficient mouse (i.e. elevated...

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PMID: 8631974
DOI: 10.1074/jbc.271.7.3639

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Related research

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Research trail→

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Prolonged Metabolic Correction in Adult Ornithine Transcarbamylase-deficient Mice with Adenoviral VectorsPMID 8631974Read ↗

Long-Term Correction of Ornithine Transcarbamylase Deficiency by WPRE-Mediated Overexpression Using a Helper-Dependent AdenovirusSemantic proximity Read ↗

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Differences in the human and mouse amino-terminal leader peptides of ornithine transcarbamylase affect mitochondrial import and efficacy of adenoviral vectors.Semantic proximity Read ↗

Highly Efficient Functional Editing of the Native Ornithine Transcarbamylase Locus by Targeted Integration with Phenotype Correction and Restoration of Physiological Patterns of Gene ExpressionSemantic proximity Read ↗

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Recombinant Adeno-Associated Virus Integration Sites in Murine Liver After Ornithine Transcarbamylase Gene CorrectionSemantic proximity Read ↗

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