Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice.

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Article

Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice.

The Journal of biological chemistry - 25 Aug 1990

Jones S N, Grompe M, Munir M I, Veres G, Craigen W J, Caskey C T

Abstract excerpt

The sparse fur (spf) mutant mouse is a model for human X-linked ornithine transcarbamylase (OTC) deficiency. Human OTC cDNA placed under transcriptional control of the mouse OTC promoter was microinjected into fertilized oocytes of spf mice. Two founder lines of transgenic mice were phenotypically and biochemically corrected for OTC deficiency by the expression of the human gene at high levels in the small...

Topics

Animals
Chloramphenicol O-Acetyltransferase
DNA
Female
Humans
Intestinal Mucosa
Liver
Male
Mice
Mice, Mutant Strains
Mice, Transgenic
Microinjections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oocytes

Ornithine Decarboxylase

Pedigree

Phenotype

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 2387875

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2387875-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice.PMID 2387875Read ↗

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