Article
Linkage of monilethrix to the trichocyte and epithelial keratin gene cluster on 12q11-q13.
The Journal of investigative dermatology - 1 Apr 1996
Stevens H P, Kelsell D P, Bryant S P, Bishop D T, Dawber R P, Spurr N K, Leigh I M
Abstract excerpt
Monilethrix is characterized by beaded or moniliform hair, which results from the periodic thinning of the hair shaft. The beaded hair thus produced is subject to excess weathering and premature fracturing at the internodes. Clinically, monilethrix presents with short, fragile, broken hair. The f...
Topics
- Chromosomes, Human, Pair 12
- Female
- Genetic Linkage
- Hair
- Humans
- Keratins
- Male
- Multigene Family
- Mutation
- Pedigree