Article
Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant--LDHB GUA1: postulated effects on subunit structure and catalysis.
Biochimica et biophysica acta - 17 Jan 1996
Shonnard G C, Hud N V, Mohrenweiser H W
Abstract excerpt
A variant of lactate dehydrogenase (LDHB GUA1) was previously identified among the Guaymi Indians of Panama and Costa Rica. The LDHB GUA1 variant is enzymatically inactive; however, the variant subunits alter the electrophoretic mobility of the tetramers that include active LDHA and LDHB subunits...
Topics
- Alleles
- Arginine
- Base Sequence
- Binding Sites
- Catalysis
- Cloning, Molecular
- Costa Rica
- Crystallography, X-Ray
- DNA Primers
- Genetic Variation
- Humans
- L-Lactate Dehydrogenase
- Models, Molecular
- Molecular Sequence Data
- Panama
- Point Mutation
- Protein Conformation
- Sequence Analysis