Comparison between medium-chain acyl-CoA dehydrogenase mutant proteins overexpressed in bacterial and mammalian cells.

doi:10.1002/humu.1380060305

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Article

Comparison between medium-chain acyl-CoA dehydrogenase mutant proteins overexpressed in bacterial and mammalian cells.

Human mutation - 1 Jan 1995

Jensen T G, Bross P, Andresen B S, Lund T B, Kristensen T J, Jensen U B, Winther V, Kølvraa S, Gregersen N, Bolund L

Abstract excerpt

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a potentially lethal inherited defect in the beta-oxidation of fatty acids. By comparing the behaviour of five missense MCAD mutant proteins expressed in COS cells and in Escherichia coli, we can define some of these as "pure folding mutant...

Topics

Acyl-CoA Dehydrogenase
Acyl-CoA Dehydrogenases
Animals
Bacterial Proteins
Chaperonins
Escherichia coli
Gene Expression
Mutation

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