Article
T-cell chemotactic activity of cytokine LD78: a comparative study with interleukin-8, a chemotactic factor for the T-cell CD45RA+ phenotype.
International archives of allergy and immunology - 1 Jan 1993
Tanaka J, Nomiyama H, Yamamoto T, Hamada F, Kambara T
Abstract excerpt
The recombinant LD78 cytokine (rLD78) promoted migration of human peripheral T lymphocytes at concentrations from 10(-11) M to 10(-7) M, with a peak of activity at 10(-8) M. There was no difference in migration promoting activity between LD78 alpha and its variant LD78 beta. Checkerboard analysis indicated that the migration of T cells attracted by rLD78 was chemotaxis but not chemokinesis. The chemotactic...
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