Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the sex-determining region Y gene in the etiology of 46,XX maleness.

1 Mar 1993

Abstract excerpt

The condition of 46,XX maleness is characterized by testicular development in subjects who have two X chromosomes but who lack a normal Y chromosome. Several etiologies have been proposed to explain 46,XX maleness: 1) translocation of the testis-determining factor from the Y to the X chromosome, 2) mutation in an autosomal or X chromosome gene which permits testicular determination in the absence of TDF, and 3)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sexual Differentiation and Disorders
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8383144
DOI: 10.1210/jcem.76.3.8383144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the sex-determining region Y gene in the etiology of 46,XX maleness.PMID 8383144Read ↗

Clinical traits and molecular findings in 46,XX males.Semantic proximity Read ↗

Combined Leydig cell and Sertoli cell dysfunction in 46,XX males lacking the sex determining region Y gene.Semantic proximity Read ↗

46,XX sex reversal.Semantic proximity Read ↗

Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive.Semantic proximity Read ↗

Mutations and sequence variants in the testis-determining region of the Y chromosome in individuals with a 46,XY female phenotypeSemantic proximity Read ↗

The role of SRY mutations in the etiology of gonadal dysgenesis in patients with 45,X/46,XY disorder of sex development and variants.Semantic proximity Read ↗

The role of the sex-determining region of the Y chromosome (SRY) in the etiology of 46,XX true hermaphroditismSemantic proximity Read ↗

The sole presence of the testis-determining region of the Y chromosome (SRY) in 46,XX patients is associated with phenotypic variability.Semantic proximity Read ↗

46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature.Semantic proximity Read ↗

Clinical, hormonal and cytogenetic evaluation of 46,XX males and review of the literature.Semantic proximity Read ↗

A novel sex-determining region on Y (SRY) nonsense mutation identified in a 45,X/47,XYY female.Semantic proximity Read ↗

Loss of sequences 3' to the testis-determining gene, SRY, including the Y pseudoautosomal boundary associated with partial testicular determination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.