Demonstration of coxsackie virus RNA in formalin‐fixed tissue sections from childhood myocarditis cases by <i>in situ</i> hybridization and the polymerase chain reaction

Abstract excerpt

This is a combined study using in situ hybridization and the polymerase chain reaction to investigate the presence of Coxsackie virus RNA in formalin-fixed tissue from cases of childhood myocarditis. Of the ten cases studied, two were positive by both methods. The virus RNA was predominantly located in areas showing an inflammatory cell infiltrate and myofibre necrosis. These findings suggest that direct lytic...

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