Article
Incest diagnosis by comparison of alleles of mother and offspring at highly heterozygous loci.
Transfusion - 1 Feb 1994
Wenk R E, Chiafari F A, Houtz T
Abstract excerpt
BACKGROUND: Methods that detect a child's homozygosity by examination of allelic products are insensitive for diagnosing incest because, at a given locus, a homozygous state is expected with a frequency of only 0.25 when parents are first-degree relatives. Furthermore, these methods are not specific if the population contains many homozygous individuals or silent alleles that cause apparent homozygosity. STUDY...
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