Article
Very early analysis of graft establishment after allogeneic bone marrow transplantation using the polymerase chain reaction.
British journal of haematology - 1 Sept 1993
O'Reilly J, Meyer B, Stoner M, Erber W, Herrmann R, Davies J
Abstract excerpt
We have used minisatellite polymorphisms flanking the apolipoprotein B locus and PCR to demonstrate the emergence of donor specific alleles in peripheral blood at 3-7 d post allogeneic bone marrow transplantation (BMT). This technique affords a very early indication of the establishment of stable engraftment, and may identify patients at risk of graft failure or leukaemic relapse. Patterns of T-cell chimaerism in...
Topics
- Alleles
- Apolipoproteins B
- Bone Marrow Transplantation
- Graft Survival
- Humans
- Leukemia
- Leukocyte Count
- Polymerase Chain Reaction
- Postoperative Period
- Transplantation Chimera
