Article
Familial cutaneous melanoma and two-mutational-event modeling.
Cancer - 1 Dec 1993
Duke D, Castresana J, Lucchina L, Lee T H, Sober A J, Carey W P, Elder D E, Barnhill R L
Abstract excerpt
BACKGROUND: According to the Knudson two-mutational-event theory, two mutations at a genetic locus may be required for the development of some cancers. Persons who have inherited a defect in one chromosome and therefore require only one more mutation for cancer development are at a higher risk of manifesting cancer at a younger age than persons without an inherited mutation, who need two acquired "hits." This...
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