Article
Familial cutaneous melanoma and two-mutational-event modeling.
Cancer - 1 Dec 1993
Duke D, Castresana J, Lucchina L, Lee T H, Sober A J, Carey W P, Elder D E, Barnhill R L
Abstract excerpt
BACKGROUND: According to the Knudson two-mutational-event theory, two mutations at a genetic locus may be required for the development of some cancers. Persons who have inherited a defect in one chromosome and therefore require only one more mutation for cancer development are at a higher risk of...
Topics
- Age Factors
- Age of Onset
- Aged
- Aged, 80 and over
- Case-Control Studies
- Humans
- Hutchinson's Melanotic Freckle
- Melanoma
- Middle Aged
- Models, Genetic
- Mutation
- Retrospective Studies
- Skin Neoplasms