Article
A mutation affecting expression of a major outer membrane protein of Moraxella catarrhalis alters serum resistance and survival in vivo.
The Journal of infectious diseases - 1 Nov 1993
Helminen M E, Maciver I, Paris M, Latimer J L, Lumbley S L, Cope L D, McCracken G H, Hansen E J
Abstract excerpt
A major outer membrane protein (CopB) of Moraxella catarrhalis is a target for antibodies that enhance clearance of this organism from the lungs of mice. A mini-Tn10kan transposon was inserted into the cloned copB gene from M. catarrhalis O35E, and an isogenic mutant unable to express the CopB pr...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Blood Bactericidal Activity
- Disease Models, Animal
- Humans
- Lung Diseases
- Mice
- Moraxella catarrhalis
- Mutagenesis, Insertional
- Mutation
- Neisseriaceae Infections
- Restriction Mapping
- Virulence