Article
A mutation affecting expression of a major outer membrane protein of Moraxella catarrhalis alters serum resistance and survival in vivo.
The Journal of infectious diseases - 1 Nov 1993
Helminen M E, Maciver I, Paris M, Latimer J L, Lumbley S L, Cope L D, McCracken G H, Hansen E J
Abstract excerpt
A major outer membrane protein (CopB) of Moraxella catarrhalis is a target for antibodies that enhance clearance of this organism from the lungs of mice. A mini-Tn10kan transposon was inserted into the cloned copB gene from M. catarrhalis O35E, and an isogenic mutant unable to express the CopB protein was constructed by transforming this mutated gene into the wild-type strain. The mutant grew at the same rate as...
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