Article
Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate.
Human mutation - 1 Jan 1994
Bisgaard M L, Fenger K, Bülow S, Niebuhr E, Mohr J
Abstract excerpt
The nationwide Danish polyposis register includes all known Danish cases of familial adenomatous polyposis (FAP) and their relatives. By identifying all FAP patients born between 1920 and 1949, we found the frequency of the disease to be 1 in 13,528. By comparing the number of affected and nonaffected offspring born to affected parents during the same period we found the penetrance of the disease for inherited...
Topics
- Adenomatous Polyposis Coli
- Aged
- Chromosomes, Human, Pair 5
- Colorectal Neoplasms
- Denmark
- Female
- Fertility
- Gene Frequency
- Humans
- Male
- Middle Aged
- Mutation