Article
Combined factor VIII/factor XI deficiency may cause intra-familial clinical variability in haemophilia A among Ashkenazi Jews.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Feb 1994
Berg L P, Varon D, Martinowitz U, Wieland K, Kakkar V V, Cooper D N
Abstract excerpt
Heterozygous factor XI deficiency occurs very frequently among Ashkenazi Jews. To investigate the potential influence of a co-inherited factor XI deficiency state on the clinical phenotype of mild/moderate haemophilia A, 28 unrelated haemophiliacs of Jewish origin were screened for the two most c...
Topics
- Base Sequence
- Deoxyribonucleases, Type II Site-Specific
- Factor XI Deficiency
- Hemophilia A
- Jews
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction